Persistent or Acquired Aganglionosis This problem may be due to an error in histological analysis, a transition zone pull-through or loss of ganglion cells and can be diagnosed by performing a biopsy above the colo-anal anastomosis. The specimen from the original operation should be reviewed and further sections should be taken circumferentially at the resection margin since the transition zon
Chronic constipation is observed in post ileoanal pull through for total colonic aganglionosis. Myectomy has been done. But still they have very spastic internal sphincters. There is no obstructing cuff or kinking of loop.